Detalhe da pesquisa
1.
Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut.
EMBO J
; 41(17): e109997, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35686465
2.
Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis.
Hepatology
; 79(4): 882-897, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999536
3.
Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease.
J Biol Chem
; 299(8): 104946, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37348559
4.
Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.
J Hepatol
; 77(3): 735-747, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35421426
5.
A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy.
EMBO J
; 36(12): 1755-1769, 2017 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446510
6.
MicroRNA-210 Promotes Bile Acid-Induced Cholestatic Liver Injury by Targeting Mixed-Lineage Leukemia-4 Methyltransferase in Mice.
Hepatology
; 71(6): 2118-2134, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31549733
7.
Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.
J Biol Chem
; 294(22): 8732-8744, 2019 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996006
8.
Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption.
Gastroenterology
; 156(4): 1052-1065, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30521806
9.
Transcriptional regulation of autophagy by an FXR-CREB axis.
Nature
; 516(7529): 108-11, 2014 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25383523
10.
A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity.
EMBO J
; 34(2): 184-99, 2015 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25425577
11.
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
J Biol Chem
; 292(42): 17312-17323, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28808064
12.
Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.
Genes Dev
; 23(8): 986-96, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19390091
13.
Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.
Hepatology
; 62(1): 220-31, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25545350
14.
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor ß-Klotho.
Proc Natl Acad Sci U S A
; 109(40): 16137-42, 2012 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22988100
15.
Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes.
J Biol Chem
; 288(32): 23252-63, 2013 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23824184
16.
Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice.
bioRxiv
; 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38045226
17.
Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.
Protein Sci
; 33(4): e4938, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38533551
18.
Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice.
Hepatology
; 56(1): 108-17, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22278336
19.
Paradoxical feeding activation of gut lipophagy by FGF15/FGF19-NR0B2/SHP-TFEB.
Autophagy
; 19(2): 742-743, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35913833
20.
MicroRNA regulation of AMPK in nonalcoholic fatty liver disease.
Exp Mol Med
; 55(9): 1974-1981, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37653034